IISC Biological Sciences Entrance Papers

Here I am looking for the previous year question paper of IISc - Entrance test of Biological Sciences, can you please provide me the same???

As you are looking for the previous year question paper of IISc - Entrance test of Biological Sciences, so here I am sharing the same with you

1. A nick in a DNA moIecule can be detected by which of the following methods?
(A) Nested PCR
(B) Primer extcnsion
(C) RT-PCR
(Dl Karyotyping

2. The stmcture of a double-stranded DNA in a palindrornic sequence is
(A) G-quartets
(B) Triplex DNA
(C) Hairpin DNA
(D) Crucifonn DNA

3. The enzyme responsible for indefinite growth of human cancer cells is
(A) Telomerase
(B) DN A polymerase 1
(C) RNA polymerase
(D) Reverse lranscriptase

4. Spontaneous deamination in a DNA stored at -20°C will lead to conversion of cytosine into
(A) Thymine
(B) Guanine
(C) Adenine
(D) Uracil

5. Whicli of the following does NOT apply to iriplex DNA
(A) II is triple-stranded DNA
(B) Requires onIy Hoogsteen hydrogen bonding
(C) Requires Watson-Crick hydrogen bonding
(D) Forms at neuhl or acidic pH

6. Tlie replicative polymerase in E. coli is
(A) - DNA polyrnerase 1
(B) DNA polymerase Ii
(C) DNA polyrnerase m
@) DNAprimase

7. A DNA chip contains a complete set of random hexanucleotide (6-mers) probes. Out of the
4" 4096 probes, how many wiI1 form perfect complemcntary duplcxes wi th sequences
within the 14 nucleotide singleshanded target DNA, 5' -GAACTGCAlTGATA-3'?

8. A major deviation from Mendel s laws occurs because of
(A) Linkage
(B) Mutation
(C) Reversion
@) Complementation

9. A mixture of 50-mer oligonucleotide and free nucleotides was loaded onro a Sephadex G-50
gel filfration column, which of the following results can be expected?
(A) The oligonucleotide and the nucleotidcs would be retained in the column and they both
can bind the resin
(B) The oligonucleotide would elute first
(C) Nucleotide would elute first
(D) Both CO-elute on this column

10. Mcthylation of glutamate residues is typically associated with
(A) Chemotaxis in bacteria
(B) Nuclear translocation in eukaryotes
(C) Restriction in bacteria
(D) Inter-celluIar transport in p1anis

11. Solute movement through which channel is mainIy responsible for the resting voltage?
(A) Porin
(B) Gap junction
(C) Glucose
(D) Potassium

12. Ribonuclease has four disulfide bonds which were reduced by Dithiothreitol in presence of
SM urca. These reagents wcre rernoved by diaIysis so rhal the prolein could refoId and ihe
disulfide bonds reformed. If he refonnation of S-S bonds occurred randomly, he expected
rccovery of [he biological activiiy would be
(A) 100%
(B) 80%
(C> 0.95 %
(D) 95 %
13. Myoglobin has 153 amino acid residues. If it was a continuous d-helix, the Iength of
myoglobin would be
(A) 36 nm
(B) 53 nni
(C) 55 nrn
(D) 23 nrn

14. The V,,, of an enzyrne was 90 pmoIeslmin/mg of protein. IT the molecular mass of the
enzyme is 20,000 Da, the tumover nurnber (min -') of thc enxyrne ic
(A) 180
@) 1800
(C) 90
(Dl 18

1 5. Wiiich or the following are most likely to be unstable?
(A) Holocentric chromosomes in C. elegans
(B) Melacentric chromosomes in humans
(C) Dicentric chromosomes in yeast
(D) Monocentric chromosomes in mice

16. Thc peptide bond is not
(A) apolar
(B) apartialdoublebond
(C) planar
(D) t r a ~ ~ s in proteins

17. The Bohr effect in hemoglobin refers to the
(A) reduced &nity for O2 at lowerpH
(B) higher pH in actively metabolizing tissues
(C) increased aff-ity for O2 at lower pH
(D) low pH in actively metabolizing tissues

(A) is found primanly in mucosaI secretions
(B) is one of h e less common immunoglobulin typcs
(C) has the highest molecular weight of all immunoglobulins
(D) contains carbohydrate covalently attachcd to thc hcavy chain

19. Which of the following genes is defeciivc in patients suffcring fiom sevcrc cornbined
immunodeficiency syndrome?
(A) cysticfibrosis~ansmembraneconductor rcgulator(CFTR)
(B) adenosine deaminase
(C) ribonucleotide reductase
(D) alpha 2 microglobulin

20. For which of he following diseases, a recombinant vaccine is available
(A) Hepatitis A
(3) Hepatitis C
(C) Hepatitis B
(D) 1-Iepatitis E

21. Which of the following molecules is a poor immunogen in children?
(A) Bacterial polysaccharides
(B) Cholera toxoid
(C) Killedrabiesvirus
(D) Live attcnuated polio virus

22. Which of thc following proteins is NOT required for the growth of Saccl~aronryces
cerevisiae celis in a medium containing glucose as ihe sole carbon source?
(A) Phosphoglyccrate kinase
(B) GAPDH
(C) Hexokinase
(D) Cytochrome C
.
Rest of the Questions are attached in below file which is free of cost

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IISc of Biological Sciences Entrance Exam Question Paper.pdf (494.9 KB, 77 views)

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