World Health Organization Europe Air Quality Guidelines

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Qualitative assessment of carcinogenicity
The decision to consider a substance as a carcinogen is based on the qualitative evaluation of all available information on carcinogenicity, ensuring that the association is unlikely to be due to chance alone. Here the classification criteria of the International Agency for Research on Cancer (IARC) have been applied (Box 1). In dealing with carcinogens, a “general rule” and exceptions from this were defined. The “general rule” states that for compounds in IARC Groups 1 and 2A (proven human carcinogens, and carcinogens with at least limited evidence of human carcinogenicity), guideline values are derived with the use of quantitative risk assessment with lowdose risk extrapolation. For compounds in Groups 2B (inadequate evidence in humans but sufficient evidence in animals), 3 (unclassifiable as to carcinogenicity in humans) and 4 (noncarcinogenic), guideline values are derived with the use of a threshold (uncertainty factor) method. For compounds in Group 2B, this may incorporate a separate factor for the possibility of a carcinogenic effect in humans.

For see complete guidelines you can free download attached pdf file.

Attached Files Available for Download

World Health Organization Europe Air Quality Guidelines.pdf (1.00 MB, 25 views)

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