PHD Entrance exam in Pharmaceutical Sciences

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PHD Entrance exam syllabus of Pharmaceutical Sciences::

SYLLABUS FOR Ph.D ENTRANCE TEST IN PHARMACEUTICAL CHEMISTRY

Unit I.
1) Physicochemical properties in relation to drug action; metabolic transformation of drugs and
its role in development of new drug molecules; metabolic antagonism.

2) Stereochemical aspects of drug receptor interactions and mechanism of drug interaction.
Isosterism and bioisosterism as guides to structural variations; Concepts of conformational
analysis and its role in design and development of new drug molecules.
3) Principle of drug design: Analogue synthesis versus rational design; discovery of lead
compounds, Pharmacophoric identification, Prodrugs and soft drug.

Unit II.
QSAR and introduction to molecular modeling.
Following name reactions and their application in the synthesis of some medicinal agents.
(a) Claisen- Schmidt reaction.
(b) Perkins reaction
(c) Friedal Craft Reaction
(d) Aldol condensation
(e) Mannich reactions.
(f) Beckmann’s rearrangement.
(g) Wagner-Meerwein rearrangement
(h) Wittig Reaction
(i) Oppenaur oxidation.
(j) (Meervein- pondroff-verley) M.P.V. Reduction.

Unit III.
Natural products as leads for new pharmaceuticals obtained from terrestrial and microbial
sources will be discussed in the light of various degradative and synthetic approaches. Important
members representing the following classes of natural products shall be discussed.

a) Alkaloids:
General introduction and classification, isolation and purification methods, general methods
employed for determining the structure of alkaloids, constitution of morphine, reserpine and
quinine.

b) Steroids:
General introduction, stereochemistry, nomenclature and structure elucidation of sterols
(cholesterol), sapogenin (diosgenin) and cardiac glycosides.

c) Amino Acids, Peptides and Nucleic acids :General introduction, synthesis of peptides and
amino acids. End group analysis, structural features of Insulin, vasopressin and oxytocin.

d) Antibiotics: Classification of antibiotics, structural details of penicillins and tetracyclines,
polypeptide antibiotics.
e) Flavonoids: Detailed chemical account of rutin and quercetin.
f) Triterpenoids: A general chemical treatment and structural elucidation of terpenoids.

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Following are the entrance exam held in India for admission in PhD courses.

CSIR-UGC NET exam
Exam held in: June and December,

NCBS
Exam held in: December,

DBT
Exam held in: February

TIFR
Exam held in: November

ICMR
Exam held in: July

NIMHANS
Exam held in: February

JNU PhD Entrance
Exam held in: May

GATE
Exam held in: Feb

Manipal University

NIPER PhD Entrance Exam
Exam held in: June

Universityof Hyderabad PhD Entrance Exam
Exam held in: June

GTU PhD Entrance Exam
Exam held in: April

National Brain Research Centre, PhD Entrance Exam
Exam held in: May

BITS Pilani PhD Entrance Examination
Exam held in: June /July

AIIMS PhD Entrance Exam,
Exam held in: Jan, July

IISC PhD Entrance Exam
Exam held in: April

NDRI PhD entrance exam,
Exam held in: June

BabasahebBhimrao Ambedkar University Lucknow - PhD Admissions Test


Bhabha Atomic Research Centre (BARC) PhD Admission Test
Exam held in: February

Indian Agricultural Research Institute PhD Entrance Exam,

IISER Indian Institute of Science Education and Research Mohali PhD Admission
No entrance, GATE, ICMR, CSIR qualified can apply

Indian Institute of Technology (IIT) Guwahati - PhD Admissions Test
Exam held in: Based on CGPA

Indian Veterinary Research Institute Bareilly PhD Admission Test
Exam held in: May

BINC February
Exam held in: March

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