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Old January 30th, 2018, 09:57 AM
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Default Council Of Scientific And Industrial Research Exam Syllabus

Hi buddy here I am looking for Council Of Scientific And Industrial Research Exam Life Sciences paper Syllabus, so will you plz provide me same here ?
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Old January 30th, 2018, 10:00 AM
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Default Re: Council Of Scientific And Industrial Research Exam Syllabus


As you want here I am giving below Council Of Scientific And Industrial Research Exam Life Sciences paper Syllabus,


MOLECULES AND THEIR INTERACTION RELAVENT TO BIOLOGY
A. Structure of atoms, molecules and chemical bonds.
B Composition, structure and function of biomolecules (carbohydrates, lipids,
proteins, nucleic acids and vitamins).
C. Stablizing interactions (Van der Waals, electrostatic, hydrogen bonding, hydrophobic
interaction, etc.).
D Principles of biophysical chemistry (pH, buffer, reaction kinetics, thermodynamics,
colligative properties).
E. Bioenergetics, glycolysis, oxidative phosphorylation, coupled reaction, group
transfer, biological energy transducers.
F. Principles of catalysis, enzymes and enzyme kinetics, enzyme regulation, mechanism of
enzyme catalysis, isozymes
G. Conformation of proteins (Ramachandran plot, secondary structure, domains, motif
and folds).
H. Conformation of nucleic acids (helix (A, B, Z), t-RNA, micro-RNA).
I. Stability of proteins and nucleic acids.
J. Metabolism of carbohydrates, lipids, amino acids nucleotides and vitamins.
2.
CELLULAR ORGANIZATION
A)
Membrane structure and function
(Structure of model membrane, lipid bilayer and membrane protein diffusion, osmosis,
ion channels, active transport, membrane pumps, mechanism of sorting and regulation
of intracellular transport,electrical properties of membranes).
B)
Structural organization and function of intracellular organelles (Cell wall, nucleus,
mitochondria, Golgi bodies, lysosomes, endoplasmic reticulum, peroxisomes, plastids,
vacuoles, chloroplast, structure & function of cytoskeleton and its role in motility).
C)
Organization of genes and chromosomes (Operon, unique and repetitive DNA,
interrupted genes, gene families, structure of chromatin and chromosomes,
heterochromatin, euchromatin, transposons).
D)
Cell division and cell cycle (Mitosis and meiosis, their regulation, steps in cell cycle,
regulation and control of cell cycle).
E)
Microbial Physiology (Growth yield and characteristics, strategies of cell division,
stress response)
3.
FUNDAMENTAL PROCESSES
A)
DNA replication, repair and recombination (Unit of replication, enzymes involved,
replication origin and replication fork, fidelity of replication, extrachromosomal replicons,
DNA damage and repair mechanisms, homologous and site-specific recombination).
B)
RNA synthesis and processing (transcription factors and machinery, formation of
initiation complex, transcription activator and repressor, RNA polymerases, capping,
elongation, and termination, RNA processing, RNA editing, splicing, and
polyadenylation, structure and function of different types of RNA, RNA transport).
C)
Protein synthesis and processing (Ribosome, formation of initiation complex, initiation
factors and their regulation, elongation and elongation factors, termination, genetic code,
aminoacylation of tRNA, tRNA-identity, aminoacyl tRNA synthetase, and translational
proof-reading, translational inhibitors, Post- translational modification of proteins).
D)
Control of gene expression at transcription and translation level (regulating the
expression of phages, viruses, prokaryotic and eukaryotic genes, role of chromatin in
gene expression and gene silencing).
4. Cell communication and cell signaling
A)
Host parasite interaction Recognition and entry processes of different
pathogens like bacteria, viruses into animal and plant host cells, alteration of host
cell behavior by pathogens, virus-induced cell transformation, pathogen-induced
diseases in animals and plants, cell-cell fusion in both normal and abnormal
cells.
B)
Cell signaling Hormones and their receptors, cell surface receptor, signaling
through G-protein coupled receptors, signal transduction pathways, second
messengers, regulation of signaling pathways, bacterial and plant two-
component systems, light signaling in plants, bacterial chemotaxis and quorum
sensing.
C)
Cellular communication Regulation of hematopoiesis, general principles of cell
communication, cell adhesion and roles of different adhesion molecules, gap
junctions, extracellular matrix, integrins, neurotransmission and its regulation.
D)
Cancer
Genetic rearrangements in progenitor cells, oncogenes, tumor suppressor genes,
cancer and the cell cycle, virus-induced cancer, metastasis, interaction of cancer
cells with normal cells, apoptosis, therapeutic interventions of uncontrolled cell
growth.
E)
Innate and adaptive immune system Cells and molecules involved in innate
and adaptive immunity, antigens, antigenicity and immunogenicity. B and T cell
epitopes, structure and function of antibody molecules. generation of antibody
diversity, monoclonal antibodies, antibody engineering, antigen-antibody
interactions, MHC molecules, antigen processing and presentation, activation
and differentiation of B and T cells, B and T cell receptors, humoral and cell-
mediated immune responses, primary and secondary immune modulation, the
complement system, Toll-like receptors, cell-mediated effector functions,
inflammation, hypersensitivity and autoimmunity, immune response during
bacterial (tuberculosis), parasitic (malaria) and viral (HIV) infections, congenital
and acquired immunodeficiencies, vaccines

Council Of Scientific And Industrial Research Exam Life Sciences paper Syllabus



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